Boilermakers Fletcher Loyer and Omer Mayer each added 18 points in a victory that marked Purdue's highest point total in the series since 1998 and largest margin since 1969. The win ended Purdue's two-game losing streak against Indiana and came three days after the Boilermakers lost to top-ranked Michigan.
Lamar Wilkerson scored 20 points for Indiana, which lost its second straight to a top-10 team. Purdue took control early with an 11-4 spurt and led wire-to-wire in what could be the final home game for Purdue's senior starters Kaufman-Renn, Smith and Loyer.